Impact of maternal HIV-1 infection on perinatal outcome

Int J Gynaecol Obstet. 1995 May;49(2):137-43. doi: 10.1016/0020-7292(95)02356-h.


Objectives: To study the impact of HIV-1 infection on pregnancy and maternal and early fetal outcome.

Method: From January 1992 to January 1993, 160 HIV-1 seropositive women and 164 HIV-1 seronegative age- and parity-matched pregnant tribal women from Manipur, India, were recruited into a prospective study. Mother and infant were followed until 6 weeks postpartum.

Results: Nine percent (15/160) of subjects had AIDS (CDC IV), 38% (60/160) were symptomatic (CDC III) and 53% (85/160) were asymptomatic (CDC I/II). Symptomatic (CDC III/IV) HIV-1 infection is associated with a significantly increased rate of miscarriage, low birth weight, intrauterine fetal death and preterm delivery. Perinatal, infant and maternal deaths were limited to symptomatic women. HIV-1 infected women were significantly younger than their HIV-1 negative counterparts both in age and age at sexual debut. Placental membrane inflammation was significantly higher in the seropositive group and this correlated well with a higher risk of preterm delivery and postpartum endometritis. Asymptomatic HIV-1 infection was not associated with adverse pregnancy outcome.

Conclusion: Symptomatic (CDC III/IV) HIV-1 infection in Indian tribal women is associated with adverse maternal and fetal outcome.

MeSH terms

  • Acquired Immunodeficiency Syndrome / diagnosis
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / transmission
  • Adolescent
  • Adult
  • Female
  • Fetal Death / etiology
  • Follow-Up Studies
  • HIV Antibodies / blood
  • HIV Infections / diagnosis
  • HIV Infections / immunology
  • HIV Infections / transmission*
  • HIV-1* / immunology
  • Humans
  • India
  • Infant
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Obstetric Labor, Premature / etiology
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / immunology
  • Pregnancy Outcome
  • Prospective Studies


  • HIV Antibodies