Anti-inflammatory and diuretic activity of a new class of compounds--Schiff bases of 3-amino-2-methylquinazolin 4(3H)-ones

Indian J Physiol Pharmacol. 1995 Apr;39(2):169-72.

Abstract

Eighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Diuretics / chemical synthesis
  • Diuretics / pharmacology*
  • Diuretics / therapeutic use
  • Edema / drug therapy
  • Female
  • Furosemide / administration & dosage
  • Furosemide / pharmacology
  • Lethal Dose 50
  • Male
  • Mice
  • Phenylbutazone / administration & dosage
  • Phenylbutazone / pharmacology
  • Quinazolines / chemical synthesis
  • Quinazolines / pharmacology*
  • Quinazolines / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Schiff Bases / chemical synthesis
  • Schiff Bases / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diuretics
  • Quinazolines
  • Schiff Bases
  • Furosemide
  • Phenylbutazone