Abstract
Eighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Diuretics / chemical synthesis
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Diuretics / pharmacology*
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Diuretics / therapeutic use
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Edema / drug therapy
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Female
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Furosemide / administration & dosage
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Furosemide / pharmacology
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Lethal Dose 50
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Male
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Mice
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Phenylbutazone / administration & dosage
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Phenylbutazone / pharmacology
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Quinazolines / chemical synthesis
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Quinazolines / pharmacology*
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Quinazolines / therapeutic use
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Rats
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Rats, Sprague-Dawley
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Schiff Bases / chemical synthesis
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Schiff Bases / pharmacology
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Diuretics
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Quinazolines
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Schiff Bases
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Furosemide
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Phenylbutazone