Glycosaminoglycan polysulfate injections in lateral humeral epicondylalgia: a placebo-controlled double-blind trial

Int J Sports Med. 1995 Apr;16(3):196-200. doi: 10.1055/s-2007-972991.


The purpose of this study was to investigate the therapeutic benefit of local Glycosaminoglycan polysulfate (GAGPS) injections in the treatment of chronic epicondylalgia. The study was conducted as a prospective, placebo-controlled double-blind trial. Sixty patients with a typical history of pain for at least 3 months who attended two private orthopaedic clinics in Stockholm received 50 mg GAGPS or placebo injections, one injection a week, for five weeks. The main outcome measures were the patients' evaluation of pain in connection with daily activities with a visual analogue scale and the number of treatment failures. The follow-up period was six months. The difference in reduction of painscore (VAS) ranging between 11.1 percentage units at the half-year follow-up and 20.9 percentage units 2 weeks after the treatment period is clinically good. The number of treatment failures in the GAGPS treatment groups at the 6 week follow-up was only 4 (13%) compared with 12 (40%) of the placebo treated patients. At the half-year follow-up 5 of those who received GAGPS had experienced a recurrency. The recurrency rate is thus smaller than most of those reported in controlled studies with corticosteroids. In the GAGPS treated group 13 patients reported on local pain after some injections, 2 cases combined with local haematomas, compared with 5 cases of local pain in the placebo group. The results confirm previous good results of GAGPS injection therapy in subchronic and chronic peritendinitis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Activities of Daily Living
  • Adult
  • Chronic Disease
  • Double-Blind Method
  • Elbow
  • Female
  • Follow-Up Studies
  • Glycosaminoglycans / administration & dosage
  • Glycosaminoglycans / adverse effects
  • Glycosaminoglycans / therapeutic use*
  • Hematoma / etiology
  • Humans
  • Injections, Intralesional / adverse effects
  • Male
  • Middle Aged
  • Pain / drug therapy
  • Pain / etiology
  • Placebos
  • Prospective Studies
  • Recurrence
  • Tennis Elbow / drug therapy*
  • Treatment Failure
  • Treatment Outcome


  • Glycosaminoglycans
  • Placebos
  • A73025