Biosynthetic capacities of actinomycetes. 4. Echinoserine, a new member of the quinoxaline group, produced by Streptomyces tendae

J Antibiot (Tokyo). 1995 Jul;48(7):619-25. doi: 10.7164/antibiotics.48.619.


A new member of the quinoxaline group antibiotics has been detected by HPLC-diode-array screening. The main compound produced by Streptomyces tendae strain Tü 4031 showed a high degree of similarity in the UV-visible spectral region with echinomycin and their structural similarity was confirmed by structure elucidation using electron tandem mass spectrometry and 2D nuclear magnetic resonance. The new compound, named echinoserine, is a non-cyclic form of echinomycin, but it is not a biosynthetic precursor. Echinoserine is less antibiotically active than echinomycin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Chromatography, High Pressure Liquid
  • Echinomycin / analogs & derivatives*
  • Echinomycin / chemistry
  • Echinomycin / isolation & purification*
  • Echinomycin / pharmacology
  • Fermentation
  • Microbial Sensitivity Tests
  • Streptomyces


  • Antibiotics, Antineoplastic
  • echinoserine
  • Echinomycin