Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain

Magn Reson Med. 1995 Jun;33(6):755-9. doi: 10.1002/mrm.1910330603.


The relative distributions of N-acetylaspartate (NAA) + N-acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / analysis
  • Brain Chemistry*
  • Choline / analysis
  • Creatine / analysis
  • Dipeptides / analysis
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Male
  • Neuropeptides / analysis
  • Phosphocreatine / analysis


  • Dipeptides
  • Neuropeptides
  • Phosphocreatine
  • isospaglumic acid
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline