The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy

Magn Reson Med. 1995 Jun;33(6):862-7. doi: 10.1002/mrm.1910330620.


Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (delta H2O-Naa) in piglet brain depended linearly on temperature from 30 degrees to 40 degrees C: temperature was 286.9-94.0 delta H2O-Naa degrees C. Thalamic temperature in six normal infants was 38.1 degrees +/- 0.4 degree C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / analysis
  • Body Temperature*
  • Brain / physiology*
  • Brain Chemistry
  • Humans
  • Hydrogen-Ion Concentration
  • Infant, Newborn
  • Magnetic Resonance Spectroscopy* / methods
  • Swine


  • Aspartic Acid
  • N-acetylaspartate