Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Apr;20(4):461-5.
doi: 10.1007/BF00973103.

Effects of Linalool on Glutamatergic System in the Rat Cerebral Cortex

Affiliations

Effects of Linalool on Glutamatergic System in the Rat Cerebral Cortex

E Elisabetsky et al. Neurochem Res. .

Abstract

Linalool is a monoterpene compound reported to be a major component of essential oils in various aromatic species. Several Linalool-producing species are used in traditional medical systems, including Aeolanthus suaveolens G. Dom (Labiatae) used as anticonvulsant in the Brazilian Amazon. Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties. The present study reports an inhibitory effect of Linalool on Glutamate binding in rat cortex. It is suggested that this neurochemical effect might be underlining Linalool psychopharmacological effects. These findings provide a rational basis for many of the traditional medical use of Linalool producing plant species.

Similar articles

See all similar articles

Cited by 33 articles

See all "Cited by" articles

References

    1. Curr Opin Neurobiol. 1991 Jun;1(1):20-6 - PubMed
    1. Trends Biochem Sci. 1992 Oct;17(10):383-7 - PubMed
    1. Anal Biochem. 1974 Jul;60(1):130-141 - PubMed
    1. Trends Pharmacol Sci. 1993 Jan;14(1):13-20 - PubMed
    1. Pharmacol Rev. 1989 Jun;41(2):143-210 - PubMed

Publication types

LinkOut - more resources

Feedback