Multiple mechanisms of receptor-G protein signaling specificity

Am J Physiol. 1995 Aug;269(2 Pt 2):F141-58. doi: 10.1152/ajprenal.1995.269.2.F141.


The hormone-receptor-G protein complex transduces extracellular information into intracellular signals that ultimately regulate cellular functions in a highly specific manner. There are hundreds of receptor types that transduce signals through a relatively limited repertoire of heterotrimeric G proteins. Linear models of signaling specificity that require specific and highly selective coupling of hormone to receptor to G protein have proven inadequate to explain how highly particular signals are funneled through the G protein "bottleneck." Recent studies have uncovered a plethora of mechanisms that contribute to signaling specificity. This review focuses on the mechanisms that contribute to specificity in the interactions of receptors with G proteins.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Feedback
  • GTP-Binding Proteins / physiology*
  • Humans
  • Receptors, Adrenergic, alpha / physiology
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Receptors, Somatostatin / physiology
  • Signal Transduction*
  • Subcellular Fractions / metabolism


  • Receptors, Adrenergic, alpha
  • Receptors, Cell Surface
  • Receptors, Somatostatin
  • GTP-Binding Proteins