Gene structure of rat cholecystokinin type-A receptor

Biochem Biophys Res Commun. 1995 Aug 24;213(3):958-66. doi: 10.1006/bbrc.1995.2222.

Abstract

Little is known about the gene structure and mRNA expression of cholecystokinin type-A(CCKA) receptor in animals or in human. By screening an EMBL phage library containing partially digested Long-Evans rat DNA, we isolated 7 genomic clones covering a continuous 27 kb region over which a rat CCKA receptor gene spanned. The gene is approximately 10 kb in length containing the entire coding region of the rat CCKA receptor cDNA and consists of five exons interrupted by four introns. The expected sizes of the transcripts from the initiation sites were consistent with the results of northern blot analyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary
  • GTP-Binding Proteins / metabolism
  • Humans
  • Male
  • Molecular Sequence Data
  • Rats
  • Rats, Wistar
  • Receptor, Cholecystokinin A
  • Receptors, Cholecystokinin / genetics*
  • Sequence Homology, Amino Acid

Substances

  • DNA, Complementary
  • Receptor, Cholecystokinin A
  • Receptors, Cholecystokinin
  • GTP-Binding Proteins

Associated data

  • GENBANK/D50608