Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice

Biol Pharm Bull. 1995 Apr;18(4):634-6. doi: 10.1248/bpb.18.634.

Abstract

In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.

MeSH terms

  • Anesthesia
  • Animals
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal / pharmacology*
  • Hexobarbital / pharmacology
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Plant Extracts / pharmacology
  • Sleep / drug effects*
  • Time Factors
  • Urethane / pharmacology

Substances

  • Diterpenes
  • Drugs, Chinese Herbal
  • Lactones
  • Plant Extracts
  • Urethane
  • Hexobarbital
  • columbin