Abstract
In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.
MeSH terms
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Anesthesia
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Animals
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal / pharmacology*
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Hexobarbital / pharmacology
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Lactones / isolation & purification
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Lactones / pharmacology*
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Male
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Mice
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Mice, Inbred Strains
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Plant Extracts / pharmacology
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Sleep / drug effects*
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Time Factors
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Urethane / pharmacology
Substances
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Diterpenes
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Drugs, Chinese Herbal
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Lactones
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Plant Extracts
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Urethane
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Hexobarbital
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columbin