Linkage of a gene for dominant non-syndromic deafness to chromosome 19

Hum Mol Genet. 1995 Jun;4(6):1073-6. doi: 10.1093/hmg/4.6.1073.

Abstract

Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 19*
  • Deafness / genetics*
  • Female
  • Genes, Dominant
  • Genetic Linkage*
  • Humans
  • Male
  • Myotonin-Protein Kinase
  • Pedigree
  • Protein-Serine-Threonine Kinases / genetics

Substances

  • DMPK protein, human
  • Myotonin-Protein Kinase
  • Protein-Serine-Threonine Kinases