Excitotoxic increase of xanthine dehydrogenase and xanthine oxidase in the rat olfactory cortex

Brain Res Dev Brain Res. 1995 May 26;86(1-2):340-4. doi: 10.1016/0165-3806(95)00012-3.


Excitotoxic lesions induced by systemic injection of kainic acid, resulted in 2-3-fold increase of xanthine dehydrogenase and xanthine oxidase activities in the rat olfactory cortex 48-72 h after drug administration. A significant increase of the xanthine oxidase/dehydrogenase ratio was also observed at 4 and 48 h post-injection. No similar changes were noticed in the hippocampus. The enhancement of enzyme activity seems to be primarily a consequence of the altered cell composition in damaged area. Free radicals produced by the increased oxygen-dependent form of the enzyme could in turn aggravate the excitotoxic brain injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hippocampus / drug effects
  • Hippocampus / enzymology
  • Kainic Acid / pharmacology
  • Male
  • Neurotoxins / pharmacology*
  • Olfactory Pathways / drug effects*
  • Olfactory Pathways / enzymology*
  • Rats
  • Rats, Wistar
  • Xanthine Dehydrogenase / metabolism*
  • Xanthine Oxidase / metabolism*


  • Neurotoxins
  • Xanthine Dehydrogenase
  • Xanthine Oxidase
  • Kainic Acid