Chemoprophylaxis of multidrug-resistant tuberculous infection in HIV-uninfected individuals using ciprofloxacin and pyrazinamide. A decision analysis

Chest. 1995 Sep;108(3):712-7. doi: 10.1378/chest.108.3.712.


Study objective: To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis.

Design: Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability.

Setting: Health-care workers infected with multidrug-resistant strains of M tuberculosis.

Interventions: Prophylaxis with ciprofloxacin and pyrazinamide.

Measurements and results: We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin.

Conclusion: Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.

MeSH terms

  • Adult
  • Ciprofloxacin / adverse effects
  • Ciprofloxacin / therapeutic use*
  • Decision Support Techniques*
  • Decision Trees
  • HIV Seronegativity
  • Health Personnel*
  • Humans
  • Occupational Diseases / microbiology
  • Occupational Diseases / prevention & control*
  • Probability
  • Pyrazinamide / adverse effects
  • Pyrazinamide / therapeutic use*
  • Sensitivity and Specificity
  • Software
  • Tuberculosis, Multidrug-Resistant / prevention & control*
  • Tuberculosis, Pulmonary / prevention & control*


  • Pyrazinamide
  • Ciprofloxacin