Study objective: To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis.
Design: Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability.
Setting: Health-care workers infected with multidrug-resistant strains of M tuberculosis.
Interventions: Prophylaxis with ciprofloxacin and pyrazinamide.
Measurements and results: We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin.
Conclusion: Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.