Increased erythrocyte calcium pump activity in a kindred with familial benign hypercalcaemia

Eur J Clin Invest. 1995 Jun;25(6):378-82. doi: 10.1111/j.1365-2362.1995.tb01717.x.


The hypothesis that a global defect in cellular calcium transport may be critical in the development of familial benign hypercalcaemia (FBH) was investigated. Nine hypercalcaemic patients from a kindred with FBH and nine normal subjects were evaluated. Our results indicate that calcium pump activity in the FBH kindred was significantly higher (28%, P < 0.005) when compared to normal subjects. These findings suggest that alterations in calcium pump activity in target tissues may play a role in the development of FBH.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Biological Transport
  • Ca(2+) Mg(2+)-ATPase / metabolism
  • Calcium / metabolism
  • Calcium-Transporting ATPases / metabolism
  • Calcium-Transporting ATPases / physiology*
  • Erythrocytes / metabolism*
  • Humans
  • Hypercalcemia / metabolism*
  • Middle Aged
  • Parathyroid Hormone / blood


  • Parathyroid Hormone
  • Ca(2+) Mg(2+)-ATPase
  • Calcium-Transporting ATPases
  • Calcium