The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product

FEBS Lett. 1995 Aug 21;370(3):250-4. doi: 10.1016/0014-5793(95)00847-3.


The linotte mutant was isolated on the basis of its learning and memory deficit. Interestingly, linotte individuals carrying a null mutation are viable, indicating that the linotte gene is not required for vital functions. We show here that the linotte gene encodes a putative receptor tyrosine kinase, homologous to the human protein RYK. These products are unique among receptor tyrosine kinases, since they possess a short extra cellular domain, and a modified intracellular catalytic domain. In particular, the subdomains directly involved in ATP binding and phosphotransfer reaction display remarkable variations. These results suggest that linotte is part of a novel signal transduction cascade involved in learning and memory.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • DNA Transposable Elements
  • DNA, Complementary
  • Drosophila / genetics*
  • Genes, Insect*
  • Humans
  • Introns
  • Learning / physiology*
  • Memory / physiology
  • Molecular Sequence Data
  • Mutation
  • Receptor Protein-Tyrosine Kinases / chemistry*
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Receptors, Cell Surface / chemistry*
  • Sequence Homology, Amino Acid


  • DNA Transposable Elements
  • DNA, Complementary
  • Receptors, Cell Surface
  • RYK protein, human
  • Receptor Protein-Tyrosine Kinases

Associated data

  • GENBANK/U36584