Interventional radiology (pulmonary angiography, coil embolotherapy, and TIPS) in patients with HPS seems to provide both diagnostic data and therapeutic results of clinical importance. The case report by Riegler et al. is instructive and emphasizes the need for further prospective study to analyze the successes and failures in terms of measurable clinical variable in a procedure such as TIPS. The resolution of hypoxemia following liver transplantation and careful patient selection offers hope to patients with severe, debilitating oxygenation abnormalities caused by HPS.