Interleukin-8 and the chemokine family

Int J Immunopharmacol. 1995 Feb;17(2):103-8. doi: 10.1016/0192-0561(94)00088-6.


Two subfamilies of chemokines are distinguished depending on the arrangement of the first two of four conserved cysteines, which are either separated by one amino acid (CXC chemokines) or adjacent (CC chemokines). IL-8 and the other CXC chemokines act preferentially on neutrophils, while the CC chemokines (MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta) act on monocytes, but not neutrophils, and have additional activities toward basophil and eosinophil granulocytes, and T-lymphocytes. Several chemokine receptors have been identified, all of which belong to the seven-transmembrane-domain type and are coupled to G-proteins. The discovery of chemokines has provided the basis for the understanding of leukocyte recruitment and activation in inflammation and other disturbances of tissue homeostasis.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Chemotactic Factors / chemistry
  • Chemotactic Factors / metabolism
  • Chemotactic Factors / physiology*
  • Cytokines / chemistry
  • Cytokines / metabolism
  • Cytokines / physiology*
  • Humans
  • Inflammation / immunology*
  • Interleukin-8 / biosynthesis
  • Interleukin-8 / physiology*
  • Leukocytes / metabolism
  • Neutrophil Activation
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-8A
  • Respiratory Burst


  • Chemotactic Factors
  • Cytokines
  • Interleukin-8
  • Receptors, Interleukin
  • Receptors, Interleukin-8A
  • Calcium