Comparison of adenosine 5'-monophosphate and methacholine for the differentiation of asthma from chronic airway diseases with the use of the auscultative method in very young children

A Avital; E Picard; K Uwyyed; C Springer

doi:10.1016/s0022-3476(95)70079-x

Comparison of adenosine 5'-monophosphate and methacholine for the differentiation of asthma from chronic airway diseases with the use of the auscultative method in very young children

J Pediatr. 1995 Sep;127(3):438-40. doi: 10.1016/s0022-3476(95)70079-x.

Authors

A Avital¹, E Picard, K Uwyyed, C Springer

Affiliation

¹ Institute of Pulmonology, Hadassah University Hospital, Jerusalem, Israel.

PMID: 7658278
DOI: 10.1016/s0022-3476(95)70079-x

Abstract

Methacholine and adenosine 5'-monophosphate bronchial challenges were performed in 54 young children--39 with asthma and 15 with other chronic airway diseases (CADs), with the use of the auscultative method. Children with asthma were sensitive to both methacholine and adenosine; children with CAD responded only to methacholine. We conclude that bronchial challenge with adenosine can help differentiate asthma from CAD in young children.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Adenosine Monophosphate*
Asthma / diagnosis*
Auscultation / methods*
Auscultation / statistics & numerical data
Bronchial Provocation Tests / methods
Bronchial Provocation Tests / statistics & numerical data
Child, Preschool
Diagnosis, Differential
Double-Blind Method
Humans
Lung Diseases, Obstructive / diagnosis*
Methacholine Chloride*
Sensitivity and Specificity

Substances

Methacholine Chloride
Adenosine Monophosphate