Recurring oral giant cell lesion in a child with X-linked hypophosphatemic rickets: clinical manifestation of occult parathyroidism?

C A Stratakis; N S Mitsiades; D Sun; G P Chrousos; A O'Connell

doi:10.1016/s0022-3476(95)70081-1

Recurring oral giant cell lesion in a child with X-linked hypophosphatemic rickets: clinical manifestation of occult parathyroidism?

J Pediatr. 1995 Sep;127(3):444-6. doi: 10.1016/s0022-3476(95)70081-1.

Authors

C A Stratakis¹, N S Mitsiades, D Sun, G P Chrousos, A O'Connell

Affiliation

¹ Division of Genetics, Georgetown University Children's Medical Center, Washington, D.C., USA.

PMID: 7658280
DOI: 10.1016/s0022-3476(95)70081-1

Abstract

A 9-year-old boy with X-linked hypophosphatemic rickets had a recurring oral giant cell lesion. These lesions are relatively uncommon in children and represent a potentially aggressive disorder that is microscopically indistinguishable from the brown tumors of hyperparathyroidism. Subclinical hyperparathyroidism is not uncommon in X-linked hypophosphatemic rickets and may account for the giant cell lesion in this patient.

Publication types

Case Reports
Review

MeSH terms

Biopsy
Child
Diagnosis, Differential
Gingiva / pathology
Granuloma, Giant Cell / diagnosis*
Granuloma, Giant Cell / etiology
Granuloma, Giant Cell / pathology
Humans
Hyperparathyroidism / complications
Hyperparathyroidism / diagnosis*
Hyperparathyroidism / pathology
Hypophosphatemia, Familial / complications
Hypophosphatemia, Familial / diagnosis*
Hypophosphatemia, Familial / pathology
Male
Recurrence