[Protein subunit vaccines: example of vaccination against hepatitis B virus]

Rev Prat. 1995 Jun 15;45(12):1488-91.
[Article in French]


Hepatitis B vaccine has been used for over 10 years. It is efficient and safe. Protection of risk groups against hepatitis B virus infection is now achieved and vaccination of newborns and adolescents is a main public health problem. Bad responders are well characterized and immunomodulatory interventions (cytokines) must be tested in these patients. Response to hepatitis B vaccine is genetically determined and the possibility of vaccine induced escape mutants should lead to careful epidemiological studies of the spread of hepatitis B virus infection.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Hepatitis B Vaccines* / classification
  • Hepatitis B Vaccines* / immunology
  • Hepatitis B virus / genetics
  • Humans
  • Immunocompromised Host
  • Mutation
  • Vaccination / methods


  • Hepatitis B Vaccines