Molecular genetics of exocrine pancreatic neoplasms

Surg Clin North Am. 1995 Oct;75(5):857-69. doi: 10.1016/s0039-6109(16)46732-0.


Molecular genetic studies of pancreatic ductal adenocarcinoma have revealed the common co-existence of K-ras, p53, and MTS1 mutations. The finding of K-ras mutations in epithelial lesions of ducts suggests them as a precursor intraepithelial neoplasm. The clinical importance of this line of work can only be anticipated at present, and a fuller understanding of genetic alterations in these neoplasms is necessary.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenocarcinoma / genetics
  • Carrier Proteins
  • Cell Cycle
  • Cyclin-Dependent Kinase Inhibitor p16
  • Genes, Tumor Suppressor
  • Genes, p53
  • Genes, ras
  • Humans
  • Molecular Biology
  • Oncogenes
  • Pancreatic Neoplasms / genetics*
  • Pancreatic Neoplasms / pathology


  • Carrier Proteins
  • Cyclin-Dependent Kinase Inhibitor p16