Central retinal vein thrombosis associated with resistance to activated protein C

Am J Ophthalmol. 1995 Sep;120(3):388-9. doi: 10.1016/s0002-9394(14)72170-1.


Purpose/methods: Activated protein C resistance was recently described as a major cause of venous thrombosis. We observed a central retinal vein thrombosis in a woman with activated protein C resistance.

Results/conclusion: DNA analysis showed the patient to be heterozygous for the factor V gene mutation, which is related to activated protein C resistance. Patients with retinal vein thrombosis should be examined for activated protein C resistance.

Publication types

  • Case Reports

MeSH terms

  • DNA Mutational Analysis
  • Factor V / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Heparin / therapeutic use
  • Humans
  • Middle Aged
  • Point Mutation
  • Protein C / genetics
  • Protein C / physiology*
  • Pulmonary Embolism / genetics
  • Retinal Vein Occlusion / genetics*
  • Retinal Vein Occlusion / therapy
  • Thrombophlebitis / genetics


  • Protein C
  • Factor V
  • Heparin