The lymph node pathology of Omenn's syndrome

Am J Surg Pathol. 1995 Sep;19(9):1082-7. doi: 10.1097/00000478-199509000-00013.

Abstract

Omenn's syndrome is a rare, usually fatal immunologic disorder of infancy characterized by recurrent infections, skin lesion, lymphadenopathy, peripheral blood lymphocytosis, and eosinophilia. Histologic evaluation of a lymph node revealed total effacement of the microscopic architecture resulting from a diffuse proliferation of interdigitating reticulum cells and a depletion of B lymphocytes. The lymph node lacked a distinct cortex and had no follicle formation. The most striking feature was a diffuse hyperplasia of S-100-protein-positive nonphagocytic reticulum cells with large, pale Langerhans-like nuclei. Ultrastructural examination identified these cells to be interdigitating reticulum cells. The lymphocytes were small and predominantly of the CD8 cytotoxic/suppressor cell type.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD / analysis
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunologic Deficiency Syndromes / immunology
  • Immunologic Deficiency Syndromes / pathology*
  • Infant, Newborn
  • Lymph Nodes / immunology
  • Lymph Nodes / pathology*
  • Lymphocytes / immunology
  • Lymphocytes / pathology

Substances

  • Antigens, CD