Thymic emigration: conveyor belts or lucky dips?

Immunol Today. 1995 Jun;16(6):268-73; discussion 273-4. doi: 10.1016/0167-5699(95)80179-0.

Abstract

The thymic medulla has always seemed a rather uncomplicated compartment, simply storing mature thymocytes until they are exported to the peripheral lymphoid organs. However, as discussed here by Roland Scollay and Dale Godfrey, a careful look at recent data suggests that events in the medulla may be more complex and protracted than previously thought.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Differentiation, T-Lymphocyte / metabolism
  • Bone Marrow Cells
  • Cell Differentiation
  • Cell Division
  • Cell Movement
  • Female
  • Gene Rearrangement, T-Lymphocyte
  • Kinetics
  • Mice
  • Mice, Transgenic
  • Models, Immunological*
  • Stochastic Processes
  • T-Lymphocyte Subsets / cytology*
  • T-Lymphocyte Subsets / immunology
  • Thymus Gland / cytology*
  • Thymus Gland / embryology
  • Thymus Gland / growth & development

Substances

  • Antigens, Differentiation, T-Lymphocyte