Transgenes and gene suppression: telling us something new?

Curr Opin Cell Biol. 1995 Jun;7(3):399-405. doi: 10.1016/0955-0674(95)80096-4.


Transgenes provide unique opportunities to assess the relationship between genotype and phenotype in an organism. In most cases, introduction and subsequent expression of a transgene will increase (with a sense RNA) or decrease (with an antisense RNA) the steady-state level of a specific gene product. However, a number of surprising observations have been made in the course of many transgenic studies. We develop a hypothesis that suggests that many examples of endogenous gene suppression by either antisense or sense transcripts are mediated by the same cellular mechanism.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells
  • Humans
  • Models, Genetic
  • Prokaryotic Cells
  • RNA, Antisense / genetics
  • Suppression, Genetic*


  • RNA, Antisense