Cyclin E is expressed in neurons and forms complexes with cdk5

Neuroreport. 1995 May 30;6(8):1130-2. doi: 10.1097/00001756-199505300-00014.

Abstract

Expression of cyclin dependent kinase cdk5 and its regulator p35 has been shown in the cytoplasm of adult neurons. Here we demonstrate that another potential regulator of cdk5, cyclin E, is expressed in the nervous system and forms complexes with cdk5. Western blot analyses identifies expression of two forms of cyclin E in the mouse nervous system with the 56 kDa form mainly expressed in neurons and 51 kDa form expressed in astrocytes and oligodendrocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blotting, Northern
  • Blotting, Western
  • Cells, Cultured
  • Cerebral Cortex / cytology
  • Cerebral Cortex / metabolism
  • Cyclin-Dependent Kinase 5
  • Cyclin-Dependent Kinases*
  • Cyclins / biosynthesis*
  • Gene Expression
  • Mice
  • Neurons / metabolism*
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Spinal Cord / cytology
  • Spinal Cord / metabolism

Substances

  • Cyclins
  • Cyclin-Dependent Kinase 5
  • Protein Serine-Threonine Kinases
  • Cdk5 protein, mouse
  • Cyclin-Dependent Kinases