Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert

Neuroreport. 1995 May 30;6(8):1219-22. doi: 10.1097/00001756-199505300-00036.

Abstract

Repeated administration of tolcapone, an inhibitor of catechol-O-methyltransferase, was able to partially restore the memory deficits caused by bilateral cholinotoxin (AF64A) lesions in the basal magnocellular nuclei of Meynert. The 2-week tolcapone treatment (3 mg kg-1, once a day) was started 24 h before toxin infusion and the last injection was given 24 h before the first avoidance test. The beneficial action of tolcapone may be related to antioxidant properties of nitrocatechols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Benzophenones / pharmacology*
  • Catechol O-Methyltransferase Inhibitors*
  • Male
  • Memory / drug effects
  • Memory Disorders / chemically induced*
  • Nitrophenols
  • Rats
  • Rats, Wistar
  • Substantia Innominata / drug effects*
  • Time Factors
  • Tolcapone

Substances

  • Benzophenones
  • Catechol O-Methyltransferase Inhibitors
  • Nitrophenols
  • Tolcapone