Controlled exposures of young asthmatics to mixed oxidant gases and acid aerosol

Am J Respir Crit Care Med. 1995 Sep;152(3):885-91. doi: 10.1164/ajrccm.152.3.7663800.

Abstract

To help assess short-term respiratory responses to summertime air pollution, we exposed 24 asthmatic volunteers aged 11-18 in a chamber to respirable acid aerosol (mass median aerodynamic diameter 0.66 micron) plus 0.3 ppm nitrogen dioxide (NO2) plus 0.2 ppm ozone (O3). The aerosol contained available hydrogen ions (H-) at an average concentration of 2.6 mumol/m-, equivalent to 127 micrograms/m3 sulfuric acid (H2SO4); some H+ probably was in NH4HSO4 rather than H2SO4. The volunteers were exposed separately to O3/NO2 without acid and to clean air. Exposures lasted 90 min, including three 15-min exercise sessions with ventilation averaging 32 L/min, at 21 degrees C and 50% relative humidity. Asthma medications were withheld before and during exposures. Subjects gargled lemonade to minimize acid neutralization by oral ammonia (NH3). Exercise-induced bronchospasm was evident in all exposures. Differences in group mean lung function response among H2SO4/O3/NO2, O3/NO2, and clean-air exposures were not statistically significant. Individuals' measured oral NH3 concentrations or estimated inhaled doses of H2SO4 did not significantly predict their lung function changes. A few subjects showed unfavorable function changes during pollutant exposures, which might be chance occurrences or might indicate the existence of an acid-pollution-susceptible subgroup among young asthmatic subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Air Pollutants / pharmacology*
  • Asthma / physiopathology*
  • Atmosphere Exposure Chambers
  • Child
  • Female
  • Forced Expiratory Volume
  • Humans
  • Male
  • Oxidants, Photochemical / pharmacology*
  • Respiration / drug effects*
  • Respiration / physiology
  • Respiratory Function Tests
  • Sulfuric Acids / pharmacology*

Substances

  • Air Pollutants
  • Oxidants, Photochemical
  • Sulfuric Acids