Genomic structure of the human TATA-box-binding protein (TBP)

Gene. 1995 Aug 19;161(2):277-82. doi: 10.1016/0378-1119(95)00209-o.

Abstract

The gene encoding the human TATA-box-binding protein (hTBP) is contained within a 20-kb DNA fragment and is split into eight exons. The coding sequence is interrupted by six introns and the 5'-untranslated region (5'-UTR) of the gene by a 2.5-kb intron. A comparison of the hTBP exon/intron organization with the various TBP cloned to date is presented.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • Exons
  • Female
  • Genome, Human
  • Humans
  • Introns
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Pregnancy
  • Protein Structure, Tertiary
  • Species Specificity
  • TATA Box
  • TATA-Box Binding Protein
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*

Substances

  • DNA, Complementary
  • DNA-Binding Proteins
  • TATA-Box Binding Protein
  • Transcription Factors