Expression of MAGE genes in transitional-cell carcinomas of the urinary bladder

Int J Cancer. 1995 Feb 20;64(1):60-4. doi: 10.1002/ijc.2910640112.


Human genes MAGE-1 and MAGE-3 code for distinct antigens, which are recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). These antigens may constitute useful targets for anti-cancer immunotherapy, since no expression of MAGE genes has been observed in normal tissues other than testis. Out of 57 samples of primary transitional-cell carcinomas of the bladder, 12 (21%) expressed MAGE-1 and 20 (35%) expressed MAGE-3. All but one of the tumors expressing MAGE-1 also expressed MAGE-3. Genes MAGE-2 and MAGE-4, which are closely related to MAGE-1 and MAGE-3, were expressed by 30% and 33% of the tumors respectively. MAGE expression was more frequent in advanced tumor stages: 61% of the invasive tumors (stage > or = T2) were positive for expression of at least one of the four genes, whereas only 28% of the superficial tumors (stages Ta and T1) expressed these genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Neoplasm / genetics*
  • Base Sequence
  • Carcinoma, Transitional Cell / genetics*
  • DNA Primers / chemistry
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Melanoma-Specific Antigens
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics*
  • Urinary Bladder Neoplasms / genetics*


  • Antigens, Neoplasm
  • DNA Primers
  • MAGEA1 protein, human
  • MAGEA3 protein, human
  • Melanoma-Specific Antigens
  • Neoplasm Proteins
  • RNA, Messenger
  • RNA, Neoplasm