Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

Trends Biochem Sci. 1995 Aug;20(8):303-7. doi: 10.1016/s0968-0004(00)89056-8.


Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence between two major cellular signalling systems: those involving G-protein-coupled receptors and those involving receptor tyrosine kinases. Importantly, wortmannin can enter intact cells, making whole-cell studies of the above signalling pathways possible.

Publication types

  • Review

MeSH terms

  • Androstadienes / pharmacology*
  • Molecular Probes
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositols / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors*
  • Signal Transduction / drug effects*
  • Wortmannin


  • Androstadienes
  • Molecular Probes
  • Phosphatidylinositols
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Wortmannin