Yeast DNA polymerases and their role at the replication fork

Trends Biochem Sci. 1995 Aug;20(8):319-23. doi: 10.1016/s0968-0004(00)89059-3.


The DNA polymerases of the yeast Saccharomyces cerevisiae serve as a model system for the study of the replication fork during DNA replication. To date, six S. cerevisiae DNA polymerases have been at least partially characterized (compared with four in mammals so far), with further candidates being identified as open reading frames in the yeast genome sequencing project. Here, we review the current state of knowledge of the yeast polymerases, and discuss, where possible, their biological role during DNA replication.

Publication types

  • Review

MeSH terms

  • DNA Polymerase II / metabolism
  • DNA Polymerase III / metabolism
  • DNA Replication*
  • DNA, Fungal / biosynthesis
  • DNA, Fungal / chemistry
  • DNA-Directed DNA Polymerase / metabolism*
  • Models, Genetic
  • Nucleic Acid Conformation
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae / genetics


  • DNA, Fungal
  • DNA Polymerase II
  • DNA Polymerase III
  • DNA-Directed DNA Polymerase