Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians

Ann Neurol. 1995 Sep;38(3):463-5. doi: 10.1002/ana.410380319.


As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged*
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics*
  • Data Collection
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Nigeria


  • Apolipoprotein E4
  • Apolipoproteins E