Anaphylactoid and anaphylactic reactions. Hazards of beta-blockers

Drug Saf. 1995 May;12(5):299-304. doi: 10.2165/00002018-199512050-00002.


Studies have demonstrated greater hazards associated with anaphylaxis in patients receiving beta-blockers. Serious anaphylaxis is more frequent. Evidence suggests this occurs via modulation of adenylate cyclase, which can influence release of anaphylactogenic mediators. Treatment of anaphylaxis in patients exposed to beta-blockers is complicated because therapeutic administration of epinephrine (adrenaline) may be ineffective or promote undesired alpha-adrenergic and vagotonic effects. Risk reduction efforts should be considered for patients receiving beta-blockers who are prone to experience anaphylaxis.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects*
  • Adrenergic beta-Antagonists / pharmacokinetics
  • Anaphylaxis / chemically induced*
  • Humans


  • Adrenergic beta-Antagonists