An Australian trial of ThinPrep: a new cytopreparatory technique

Cytopathology. 1995 Jun;6(3):140-8. doi: 10.1111/j.1365-2303.1995.tb00466.x.


To evaluate the sensitivity and suitability of ThinPrep, a new slide preparation technique, 2026 paired cervical cytology slides were examined. After conventional Papanicolaou smears were prepared, the sampling instruments were rinsed in a fluid fixative. ThinPrep slides were then prepared in the laboratory from the surplus cells in the fixative. Compared with the Pap smears, ThinPrep slides were easier and quicker to screen, were inconclusive less often, and had similar rates for detecting abnormalities and infection. There were more unsatisfactory ThinPrep slides and more ThinPrep slides lacked endocervical cells. Both of these shortcomings were found to be linked to the choice of sampling implements. This study, in which a variety of sampling instruments was used, fails to confirm some of the previous claims made for the new technique.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Australia
  • Female
  • Humans
  • Papanicolaou Test*
  • Sensitivity and Specificity
  • Uterine Cervical Neoplasms / pathology*
  • Vaginal Smears / instrumentation
  • Vaginal Smears / methods*