Nimodipine counteracts corticosterone-induced habituation impairments

Neurobiol Learn Mem. 1995 May;63(3):241-5. doi: 10.1006/nlme.1995.1028.

Abstract

Corticosterone or placebo sustained-release pellets (4 pellets of 200 mg each, released over 90 days) were implanted subcutaneously in young Fischer-344 rats, fed with either regular food or with food containing 860 ppm of nimodipine. Following 2 weeks of treatment, the habituation of the rats to a new environment was studied. On the first test day, placebo-implanted rats explored the new environment and exhibited a characteristic habituation. On the second test day, 48 hr later, low activity was measured in the already familiar environment. This habituation was absent in corticosterone-implanted rats fed with regular food. However, corticosterone-implanted rats fed with food containing nimodipine behaved during the second test similarly to the placebo-implanted group. The data indicated that the behavioral deficit, induced in Fischer-344 rats by the high corticosterone levels, was reversed by the nimodipine treatment. Thus, nimodipine may be useful in counteracting certain prolonged stress-related cognitive impairments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Cognition / drug effects
  • Corticosterone / pharmacology*
  • Feeding Behavior / drug effects
  • Habituation, Psychophysiologic / drug effects*
  • Male
  • Nimodipine / pharmacology*
  • Placebos
  • Rats

Substances

  • Placebos
  • Nimodipine
  • Corticosterone