TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

Cell. 1995 Sep 8;82(5):823-9. doi: 10.1016/0092-8674(95)90479-4.


Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes / genetics
  • Chromosomes / radiation effects
  • Cloning, Molecular
  • Genes, Fungal / genetics
  • Humans
  • Mitosis / genetics
  • Mitosis / radiation effects
  • Molecular Sequence Data
  • Mutation / radiation effects
  • Saccharomyces cerevisiae / genetics*
  • Sequence Homology, Amino Acid
  • Telomere / genetics*

Associated data

  • GENBANK/U31331