A long perspective on childhood multiple sclerosis

Dev Med Child Neurol. 1995 Aug;37(8):661-6. doi: 10.1111/j.1469-8749.1995.tb15010.x.


Twenty-eight patients, all of whom developed multiple sclerosis before 16 years of age and all from a well-defined geographical population (Grampian, north-eastern Scotland) were retrospectively studied. Age at presentation, presenting features and interval between first and second attacks are discussed. Follow-up ranged from three to 47 years and adult categorisation was applied to outcome. This suggested that on the whole, childhood-onset multiple sclerosis is a less aggressive disease than its adult counterpart.

MeSH terms

  • Adolescent
  • Age of Onset
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infant
  • Male
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / mortality
  • Multiple Sclerosis / physiopathology
  • Prognosis
  • Recurrence
  • Retrospective Studies
  • Scotland / epidemiology
  • Survival Rate