Protein C deficiency and stroke in early life

Dev Med Child Neurol. 1995 Aug;37(8):723-30. doi: 10.1111/j.1469-8749.1995.tb15018.x.


Plasma concentrations of protein C, protein S and antithrombin III were measured in 33 unselected children with a history of cryptogenic stroke (group 1), four children with previously ascertained low plasma concentrations of protein C following stroke (group 2) and 42 healthy children undergoing minor surgery (group 3). Protein S and antithrombin III were normal in all patients. Low concentrations of protein C were found in two patients in group 1 and in six healthy children in group 3. Low protein C concentrations returned to normal over many months in three of the four patients in group 2. Prophylactic antithrombotic therapy and/or termination of pregnancy had been carried out unneccessarily in two families in whom inherited protein C deficiency was not confirmed. The suggestion that heterozygous protein C deficiency contributes to the risk of arterial stroke was not supported by this study.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antithrombin III / analysis
  • Cerebrovascular Disorders / blood
  • Cerebrovascular Disorders / etiology*
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Male
  • Protein C / analysis
  • Protein C Deficiency*
  • Protein S / analysis


  • Protein C
  • Protein S
  • Antithrombin III