Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion

Gut. 1995 Jul;37(1):144-7. doi: 10.1136/gut.37.1.144.


A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / complications*
  • Cholestasis, Intrahepatic / therapy*
  • Chronic Disease
  • Exchange Transfusion, Whole Blood*
  • Humans
  • Hyperbilirubinemia / therapy
  • Male
  • Recurrence