Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion

A O'Callaghan; S G O'Brien; M Ninkovic; G P Butcher; C S Foster; J R Walters; I A Roberts

doi:10.1136/gut.37.1.144

Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion

Gut. 1995 Jul;37(1):144-7. doi: 10.1136/gut.37.1.144.

Authors

A O'Callaghan¹, S G O'Brien, M Ninkovic, G P Butcher, C S Foster, J R Walters, I A Roberts

Affiliation

¹ Department of Haematology, Royal Postgraduate Medical School, London.

Abstract

A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.

Publication types

Case Reports

MeSH terms

Adolescent
Anemia, Sickle Cell / complications*
Cholestasis, Intrahepatic / therapy*
Chronic Disease
Exchange Transfusion, Whole Blood*
Humans
Hyperbilirubinemia / therapy
Male
Recurrence