Abstract
Disturbances of several humoral and cellular immune parameters are significantly increased in individuals exposed to chemical pollutants. Moreover, exacerbations of the latent Epstein-Barr virus (EBV) infection were more frequently observed in the chemically exposed group than in the control groups. A significant correlation was seen between EBV exacerbations and the increased number of eosinophils, T-lymphocyte rosette formation and the respiratory burst of polymorphonuclear blood cells. Possible links between hepatopathy due to xenobiotics exposition, immunological disturbances and EBV exacerbation are discussed, including a putative role of EBV-induced (autocrine) cytokines.
MeSH terms
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Antibodies, Viral / blood
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Antibody Formation / drug effects*
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Antigens, Viral / immunology
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Chemical Industry*
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Chemical and Drug Induced Liver Injury*
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Cytokines / physiology
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Electronics
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Environmental Pollutants / adverse effects*
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Environmental Pollutants / pharmacology
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Hepatitis C / immunology
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Herpesviridae Infections / immunology*
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Herpesvirus 4, Human / drug effects*
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Herpesvirus 4, Human / immunology
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Herpesvirus 4, Human / physiology
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Humans
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Immunity, Cellular / drug effects*
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Immunocompromised Host
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Models, Immunological
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Occupational Diseases / chemically induced*
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Occupational Diseases / immunology
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Occupational Exposure*
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Oxidants / adverse effects*
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Oxidants / pharmacology
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Oxidative Stress
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Respiratory Burst
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Retrospective Studies
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Time Factors
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Virus Activation / drug effects*
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Xenobiotics / adverse effects*
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Xenobiotics / pharmacology
Substances
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Antibodies, Viral
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Antigens, Viral
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Cytokines
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Environmental Pollutants
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Oxidants
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Xenobiotics