Abstract
Escherichia coli K-12 strains that carry mutations in one or more genes coding for proteins involved in repair of deoxyribonucleic acid lesions are more sensitive to the antibiotic nitrofurantoin than are the nonmutant parent strains.
MeSH terms
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Bacterial Proteins / biosynthesis
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DNA Repair*
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DNA, Bacterial / biosynthesis
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Drug Resistance, Microbial
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Escherichia coli / drug effects*
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Escherichia coli / metabolism
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Genes
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Mutation*
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Nitrofurantoin / pharmacology*
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Recombination, Genetic
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Streptomycin / pharmacology
Substances
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Bacterial Proteins
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DNA, Bacterial
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Nitrofurantoin
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Streptomycin