Isolation and Structure of Two Novel Muscarinic Receptor Antagonists

J Nat Prod. 1995 Jun;58(6):843-7. doi: 10.1021/np50120a004.

Abstract

The structures of two novel muscarinic receptor antagonists, 1 and 2, were determined by their spectral data and high-resolution mass measurements of their degradation products. Both are aliphatic long-chain compounds and contain amide and keto functionalities. The major microbial metabolite [1] contains three terminal guanidino groups and the minor compound [2] has two terminal guanidino groups.

MeSH terms

  • Actinomycetaceae / chemistry*
  • Chromatography, High Pressure Liquid
  • Hydrolysis
  • Magnetic Resonance Spectroscopy
  • Muscarinic Antagonists / isolation & purification
  • Muscarinic Antagonists / pharmacology*
  • Quinuclidinyl Benzilate
  • Receptors, Muscarinic / drug effects*
  • Soil Microbiology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Muscarinic Antagonists
  • Receptors, Muscarinic
  • Quinuclidinyl Benzilate