Effects of mitomycin C on delayed adjustment in experimental strabismus surgery

Korean J Ophthalmol. 1995 Jun;9(1):51-8. doi: 10.3341/kjo.1995.9.1.51.


In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.

MeSH terms

  • Administration, Topical
  • Animals
  • Chemotherapy, Adjuvant
  • Conjunctiva / drug effects
  • Mitomycin / administration & dosage
  • Mitomycin / pharmacology*
  • Oculomotor Muscles / drug effects
  • Oculomotor Muscles / pathology
  • Oculomotor Muscles / surgery*
  • Ophthalmic Solutions
  • Postoperative Complications / prevention & control
  • Rabbits
  • Sclera / drug effects
  • Strabismus / drug therapy
  • Strabismus / pathology
  • Strabismus / surgery*
  • Suture Techniques
  • Tissue Adhesions / prevention & control


  • Ophthalmic Solutions
  • Mitomycin