The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta

Life Sci. 1995;57(13):PL159-63. doi: 10.1016/0024-3205(95)02079-x.


The pA2 value of several alpha 1-adrenoceptor antagonists on noradrenaline-induced contractions of rat aorta, and their affinity for the cloned alpha 1a-, alpha 1b- and alpha 1d-adrenoceptor subtypes were evaluated. Selective or moderately selective alpha 1d-, partially selective alpha 1b-, selective alpha 1a- and non subtype-selective alpha 1-adrenoceptors antagonists were included in the study. The potency of these compounds on rat aorta was well correlated with the affinity observed for the alpha 1d-adrenoceptor subtype. A poor correlation was found for the alpha 1b- and alpha 1a-subtypes. These results suggest that the alpha 1d-subtype plays a determining role in rat aorta contractions induced by noradrenaline.

MeSH terms

  • Adrenergic alpha-Antagonists / pharmacology
  • Animals
  • Aorta / physiology*
  • Ligands
  • Male
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology*
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / physiology*
  • Norepinephrine / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Adrenergic, alpha-1 / classification
  • Receptors, Adrenergic, alpha-1 / physiology*


  • Adrenergic alpha-Antagonists
  • Ligands
  • Receptors, Adrenergic, alpha-1
  • Norepinephrine