Circadian responses to light: the calmodulin connection

Neurosci Lett. 1995 Jun 9;192(2):101-4. doi: 10.1016/0304-3940(95)99209-n.

Abstract

KN-62, an inhibitor of CaM kinase II, attenuated phase shifts induced by low intensity light pulses and reduced light-induced phosphorylation of the transcription factor, CREB, in the suprachiasmatic nucleus. The calmodulin inhibitor, W-7, had similar effects: neither drug produced a complete block of photic responses. The results support the hypothesis that circadian responses to light are mediated in part by CaM kinase activity and CREB, and suggest that other signal transduction pathways also take part.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine* / analogs & derivatives*
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors
  • Calmodulin / antagonists & inhibitors
  • Calmodulin / physiology*
  • Circadian Rhythm / physiology*
  • Circadian Rhythm / radiation effects*
  • Cricetinae
  • Cyclic AMP Response Element-Binding Protein / metabolism
  • Immunohistochemistry
  • Isoquinolines / pharmacology
  • Light*
  • Male
  • Mesocricetus
  • Phosphorylation
  • Piperazines / pharmacology
  • Sulfonamides / pharmacology
  • Suprachiasmatic Nucleus / metabolism

Substances

  • Calmodulin
  • Cyclic AMP Response Element-Binding Protein
  • Isoquinolines
  • Piperazines
  • Sulfonamides
  • KN 62
  • W 7
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
  • Calcium-Calmodulin-Dependent Protein Kinases