Prenatal Lorazepam Exposure: 4. Persistent Alterations in Pentylenetetrazole-Induced Seizure Threshold and GABA-dependent Chloride Uptake After Prenatal Lorazepam Exposure

Pharmacol Biochem Behav. 1995 Aug;51(4):721-4. doi: 10.1016/0091-3057(95)00017-q.

Abstract

Prenatal benzodiazepine exposure is associated with behavioral and neurochemical alterations in the early postnatal period. To determine the persistence of these effects, we evaluated pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake in mice at 6 and 12 months of age after prenatal lorazepam exposure. Seizure threshhold was reduced after acute lorazepam pretreatment in mice exposed to lorazepam prenatally, compared to control groups, at 6 and 12 months of age. Maximal GABA-dependent chloride uptake was also reduced in exposed mice at 6 and 12 months of age. These data indicate that behavioral and neurochemical alterations persist well into maturity after prenatal lorazepam exposure.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Chlorides / metabolism*
  • Chlorine
  • Female
  • Lorazepam / pharmacology*
  • Mice
  • Muscimol / pharmacology
  • Pentylenetetrazole*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Radioisotopes
  • Seizures / chemically induced
  • Seizures / physiopathology*
  • gamma-Aminobutyric Acid / physiology*

Substances

  • Chlorides
  • Radioisotopes
  • Muscimol
  • Chlorine
  • gamma-Aminobutyric Acid
  • Lorazepam
  • Pentylenetetrazole