Axonal injury: a universal consequence of fatal closed head injury?

Acta Neuropathol. 1995;89(6):537-43. doi: 10.1007/BF00571509.


beta-Amyloid precursor protein immunostaining has recently been shown to be a reliable method for detecting the damage to axons associated with fatal head injury. In an attempt to compare the efficacy of this technique with conventional histological detection of axonal damage, we have reanalysed sections from a large well-characterised series of head-injured and control patients. The results indicate that the frequency of axonal injury has been vastly underestimated using conventional silver techniques, and that axonal injury may in fact be an almost universal consequence of fatal head injury.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloid beta-Protein Precursor / metabolism
  • Axons / metabolism
  • Axons / physiology*
  • Child
  • Child, Preschool
  • Female
  • Head Injuries, Closed / metabolism
  • Head Injuries, Closed / pathology*
  • Head Injuries, Closed / physiopathology
  • Humans
  • Immunohistochemistry
  • Intracranial Pressure / physiology
  • Male
  • Middle Aged
  • Silver Staining
  • Survival


  • Amyloid beta-Protein Precursor