Nitric oxide synthase activities in human myocardium

Lancet. 1993 Jan 9;341(8837):84-5. doi: 10.1016/0140-6736(93)92559-c.


Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Oxidoreductases / metabolism*
  • Animals
  • Calcium / metabolism
  • Cardiomyopathy, Dilated / enzymology*
  • Enzyme Induction
  • Humans
  • Myocardium / enzymology*
  • Nitric Oxide Synthase
  • Rats


  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • Calcium