Radioprotective effect of vitamins C and E

Mutat Res. 1993 Feb;301(2):143-7. doi: 10.1016/0165-7992(93)90037-v.

Abstract

Albino rats were treated with aqueous vitamin C solution and vitamin E solution dissolved in olive oil at two concentrations, 100 and 300 mg/kg/day, for 6 months. Some of the animals were then subjected to whole-body irradiation. Chromosomal aberrations and mitotic activity in non-irradiated and irradiated groups were recorded. Both vitamins were found to be non-mutagenic. Vitamin C exerted a radioprotective effect but vitamin E was not radioprotective and it suppressed the radioprotection otherwise produced by olive oil.

MeSH terms

  • Animals
  • Ascorbic Acid / pharmacology*
  • Bone Marrow / drug effects
  • Bone Marrow / radiation effects
  • Chromosome Aberrations*
  • Male
  • Mutagens / toxicity
  • Radiation-Protective Agents / pharmacology*
  • Rats
  • Vitamin E / toxicity*
  • Whole-Body Irradiation

Substances

  • Mutagens
  • Radiation-Protective Agents
  • Vitamin E
  • Ascorbic Acid